Publications & Achievements
Selected recent publications and recognition from our research group.
Recent Publications(20)
Aggregates-on-chip: a microfluidic device for crowding plant cells in culture
Alyaa Farouk Hessin, Ajymurat Orozaliev, Mohammed Ateequr Mohammed, Anh Duc Van, Bruno Guillotin, Yong-Ak Song, Kenneth D Birnbaum
Here, we develop a microfluidic device that uses arrays of cylindrical cups to gently capture and confine multiple protoplasts into stable aggregates, generating a constrained micr…
MechanoBioCAD: A Generalized Semi-Automated Computational Tool for Mechanobiological Studies
N. Baban*, C. Stubbs, Y.-A. Song
We developed a software tool based on Abaqus to measure forces of various single and multicellular organisms for mechanobiological studies.
Investigating the Mechanism of Ion Concentration Polarization within Nanofluidic Hydrogel Membranes: Experiment and Simulation
H. Aljayyousi*, J. Kim*, S. Kirmizialtin, Y.-A. Song
We conducted molecular dynamics simulations to study nanoscale phenomena of ion concentration polarization around a cation-selective membrane and found the effects of the ionic str…
Accelerating Cleavage Activity of CRISPR-Cas13 System on a Microfluidic Chip for Rapid Detection of RNA
J. Kim*, A. Orozaliev*, S. Sahloul*, A.-D. Van*, V.-T. Dang, V.-S. Pham, Y. Oh, I. Chehade, M. Al-Sayegh, Y.-A. Song
We combined the CRISPR 13a detection with the ion concentration polarization (ICP) in a single microfluidic device and enhanced its detection speed and sensitivity.
A Modular and Reconfigurable Microfluidic Device for Culturing Spheroids Under Continuous Perfusion
H. Aljayyousi*, S. Sahloul*, A. Orozaliev*, N. Baban*, A.-D. Van*, A. Al Nuairi*, P. John, A. Zam, P. Percipalle, Y.-A. Song
We developed a versatile microfluidic modular device with a reconfigurable channel design that is customizable by altering the channel configuration in the adhesive layer. The rese…
BioTrojans: Viscoelastic Microvalve-based Attacks in Flow-based Microfluidic Biochips and their Countermeasures
N. Baban*, J. Zhou, K. Elkhoury, S. Bhattacharjee, S. Vijayavenkataraman, N. Gupta, Y.-A. Song, K. Chakrabarty, R. Karri
We demonstrate a material-based biochip attack termed “BioTrojans,” which are chemically tampered and optically stealthy microvalves that can be ruptured through low-frequency actu…
3D manipulation of small multicellular organisms in soft microtubes
M. Khobdabayev*, T. Hayek*, S. Alnajjar*, L. Alkasaji*, A. Orozaliev, Y.-A. Song
We developed a soft PDMS microtube that can be gently stretched and released, immobilizing small multicellular organisms without anesthetization and damage. This tube enables easy…
High-yield, one-pot upcycling of polyethylene and polypropylene waste into blue-emissive carbon dots
9. M. Abdelhameed, M. Elbeh, N. Baban*, L. Pereira, J. Matula, Y.-A. Song, K. Ramadi
We report a facile, single-step, and organic solvent-free hydrothermal process to convert polyethylene-based plastic bags and polypropylene-based surgical masks into carbon dots wi…
Material-level countermeasures for securing microfluidic biochips
N. Baban*, S. Saha, S. Jancheska, I. Singh, S. Khapli, M. Khobdabayev*, J. Kim*, S. Bhattacharjee, Y.-A. Song, K. Chakrabarty, R. Karri
We present a dynamic material-level watermarking scheme for PDMS-based flow-based microfluidic biochips (FMBs) with microvalves using a perylene-labeled fluorescent dye. This count…
Plasmonics for neuroengineering
7. N.S. Susan Mousavi, K. Ramadi, Y.-A. Song, S. Kumar
This is an in-depth review paper that reports on the basics of plasmonics and various applications of plasmonics for neuroengineering
Biomimetic fracture model of lizard tail autotomy
N. Baban*, A. Orozaliev*, S. Kirchhof, C. Stubbs, Y.-A. Song
This paper explains the lizard tail fracture mechanism using a computational and experimental model
Biomimicking interfacial fracture behavior of lizard tail autotomy with soft microinterlocking structures
12. N. Baban*, A. Orozaliev*, S. Kirchhof, C. Stubbs, Y.-A. Song
In this paper, we have demonstrated a biomimetic model of the lizard tail fracture using pneumatically actuated soft interlocked microstructures.
Rational design of bioinspired tissue adhesives
N. Baban*, A. Orozaliev*, S. Kirchhof, C. Stubbs, Y.-A. Song
In this commentary, we have discussed the potential application of tunable adhesives in biomedical areas such as wound healing
Structural Attacks and Defenses for Flow-Based Microfluidic Biochips
10. N. Baban*, S. Saha, A, Orozaliev, J. Kim*, S. Bhattacharjee, Y.-A. Song, R. Karri, K. Chakrabarty
In this paper, we have demonstrated a structural attack on microfluidic biochips by varying the height of micro reaction chambers. We adopted two existing deep learning-based anoma…
Thwarting Bio-IP Theft Through Dummy-Valve-based Obfuscation
M. Shayan, S. Bhattacharjee, A. Orozaliev*, Y.-A. Song, K. Chakrabarty, R. Karri
In this paper, we introduce the use of a dummy valve as a security primitive to obfuscate bioassay implementations; (2) we show how dummy valves can be used to obscure biochip buil…
Biophysical analysis of drug efficacy on C. elegans models for neurodegenerative and neuromuscular diseases
S. Sofela*, S. Sahloul*, Y.-A. Song
In this paper, we have investigated the efficacy of various drugs for treating neurodegenerative and neuromuscular diseases using C. elegans models.
Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator
S. Yousuf, J. Kim*, A. Orozaliev*, M. Dahlem, Y.-A. Song, J. Viegas
In this paper, we demonstrated a suspended microring resonator for the label-free detection of morpholino-DNA hybridization inside a microfluidic chip
Microfluidic Electrokinetic Preconcentration Chip for Enhanced Detection of Nucleic Acids and Exosomes
J. Kim*, S. Sahloul*, A. Orozaliev*, V. Do, V. S. Pham, D. Martins*, X. Wei*, R. Levicky, Y.-A. Song
In this review paper, we have reviewed the latest development of microfluidic electrokinetic preconcentration for enhanced detection of nucleic acids such as DNAs and RNAs as well…
Quantitative fluorescence imaging of mitochondria in body wall muscles of Caenorhabditis elegans under hyperglycemic conditions using a microfluidic chip
S. Sofela*, S. Sahloul*, S. Bhattacharjee, A. Bose, U. Usman*, Y.-A. Song
We have developed a single-channel microfluidic device that can trap C. elegans and allow us to image the mitochondria in body wall muscles accurately and with higher throughput th…
Understanding interfacial fracture behavior between microinterlocked soft layers using physics-based cohesive zone modeling
N. Baban*, A. Orozaliev*, C. Stubbs, Y.-A. Song
In this paper, we have investigated the fracture behavior in the microinterlocked interface of soft layers experimentally as well as computationally using a FEM model